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The effects of synbiotic supplementation on glucose metabolism and lipid profiles in patients with diabetes: A systematic review and meta-analysis of randomized controlled trials

However, the timeframe is significantly off: Phase 2 was 48 weeks (about 11 months) and TRIUMPH-4 was 68 weeks (about 16 months), not 6 months

Microbial butyrate production in the human gut has been known for decades (29) before the large sequencing efforts of the gut microbiota started, but it was only in the last decade that metagenomics surveys consistently revealed in multiple independent human cohorts a decrease of butyrate-producing bacteria in individuals with T2D (19, 20)

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In contrast, the K265G and the double K265G/K301G mutants severely impaired metabolic activity and cell viability, whereas the patient-derived E366G mutation caused only a moderate reduction of both (Fig